biomarker profiling (erbb2, p53, and pr) for stage i of breast cancer

breast cancer (bc) accounts for one of the major health problems around the world. since the diagnosis process can have great effect on therapy outcomes, we studied the biomarkers specific to breast tumors stage i based on examining different iranian patients. cases from different stages were examined to discover their highly expressed proteins. in addition, pathologic evaluations were performed as the diagnosis procedure. considering positive percentage of over-expressed protein in different stages in the population, it is guessed that over-expression of erbb2 and pr are positively correlated, while p53 is in negative correlation with them. therefore, these molecules can probably account for stage i biological marker. this study suggests that alterations in over-expression of specific biomarkers in different stages may be associated to the stage classification, and can help achieve more effective therapies of this malignancy.